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San Francisco Syncope Rule

The San Francisco Syncope Rule (CHESS) flags ED syncope patients at risk of a serious outcome within 7 days if any is present: history of CHF, hematocrit <30%, abnormal ECG, shortness of breath, or triage SBP <90 mmHg. Derivation sensitivity 96%, specificity 62%.

  • History of congestive heart failure (yes/no, +1)
  • Hematocrit (%)
  • Abnormal ECG (non-sinus rhythm or new changes) (yes/no, +1)
  • Shortness of breath (yes/no, +1)
  • Triage systolic BP (mmHg or kPa)
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Interpretation

ResultMeaning
Any criterionNot low risk: consider admission/further work-up
NoneLow risk for 7-day serious outcome

Formula

C: history of CHF · H: Hct <30% · E: abnormal ECG (non-sinus rhythm or new changes) · S: shortness of breath · S: triage SBP <90 mmHg. Any = not low risk.

Clinical pearls

  • Derivation: 684 consecutive ED visits for syncope or near-syncope at one US academic centre; serious outcomes = death, MI, arrhythmia, PE, stroke, SAH, significant haemorrhage or return ED visit with hospitalisation within 7 days.
  • External validations have shown lower sensitivity (around 85–90%); use as an adjunct, not as the sole basis for discharge.
  • Patients with obvious alternative causes (seizure, trauma-induced LOC, intoxication) were excluded.

Examples

FAQ

What does CHESS stand for?

CHF history, Hematocrit <30%, ECG abnormal, Shortness of breath, Systolic BP <90 at triage.

Is the SF Syncope Rule better than the Canadian Syncope Risk Score?

The Canadian Syncope Risk Score was derived in a larger multicentre cohort with 30-day outcomes and gives graded risk; the SF rule is a simpler binary screen.

Evidence

  1. Quinn JV et al. Derivation of the San Francisco Syncope Rule to predict patients with short-term serious outcomes. Ann Emerg Med 2004;43:224–32.

Emergency & Trauma · Reviewed 2026-10-14 · Methodology