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HbA1c to Estimated Average Glucose (ADAG)

Estimated average glucose (eAG) from HbA1c by the ADAG equation: eAG (mg/dL) = 28.7 × A1c − 46.7 (mmol/L = 1.59 × A1c − 2.59). An A1c of 7% corresponds to about 154 mg/dL (8.6 mmol/L).

  • HbA1c (% or mmol/mol)
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Interpretation

ResultMeaning
5%97 mg/dL
6%126 mg/dL
7%154 mg/dL
8%183 mg/dL
9%212 mg/dL
10%240 mg/dL

Formula

eAG (mg/dL) = 28.7 × A1c (%) − 46.7; eAG (mmol/L) = 1.59 × A1c − 2.59. IFCC (mmol/mol) = (A1c% − 2.15) × 10.929

Clinical pearls

  • Individual average glucose can differ substantially from eAG (95% CI at A1c 7% is roughly 123–185 mg/dL).
  • A1c is unreliable with altered red-cell turnover: hemolysis, recent transfusion, iron deficiency, CKD, pregnancy, hemoglobinopathies.

Examples

FAQ

What average glucose is an A1c of 7%?

About 154 mg/dL (8.6 mmol/L) by the ADAG equation.

What A1c diagnoses diabetes?

An A1c of 6.5% or higher (confirmed) diagnoses diabetes; 5.7–6.4% is prediabetes.

Evidence

  1. Nathan DM et al. Translating the A1C assay into estimated average glucose values. Diabetes Care 2008;31:1473–8.

Endocrine & Metabolic · Reviewed 2026-10-14 · Methodology