AskCalc
Home › Infectious Disease › Centor / McIsaac

Centor Score (Modified / McIsaac) for Strep Pharyngitis

The McIsaac (modified Centor) score estimates the likelihood of group A streptococcal pharyngitis: 1 point each for fever >38 °C, absent cough, tender anterior cervical nodes and tonsillar swelling/exudate, +1 for age 3–14 and −1 for age ≥45. Scores ≤1 need no testing or antibiotics; 2–3 warrant a rapid strep test or culture; ≥4 warrants testing (or empiric treatment in some guidelines).

  • Age (years)
  • Temperature >38 °C (100.4 °F) (yes/no, +1)
  • Absence of cough (yes/no, +1)
  • Tender/swollen anterior cervical lymph nodes (yes/no, +1)
  • Tonsillar swelling or exudate (yes/no, +1)
—

Interpretation

ResultMeaning
≤01–2.5%: no test, no antibiotic
15–10%: no test, no antibiotic
211–17%: test
328–35%: test
≥451–53%: test or empiric treatment

Formula

Fever >38 °C +1 · absence of cough +1 · tender anterior cervical nodes +1 · tonsillar swelling/exudate +1 · age 3–14 +1 · age 15–44 0 · age ≥45 −1

Clinical pearls

  • IDSA advises against testing most adults with clear viral features (cough, rhinorrhea, hoarseness, oral ulcers) regardless of score.
  • In children, a negative rapid antigen test should be confirmed by throat culture.
  • The original Centor score (Centor 1981, adults) is the four clinical items without the age modifier.

Examples

FAQ

What Centor score needs antibiotics?

Antibiotics should be guided by a positive rapid strep test or culture; testing is recommended at a McIsaac score of 2 or more.

What is the difference between Centor and McIsaac?

McIsaac adds an age modifier (+1 for 3–14, −1 for ≥45) to the four Centor criteria and extends use to children.

Evidence

  1. McIsaac WJ et al. A clinical score to reduce unnecessary antibiotic use in patients with sore throat. CMAJ 1998;158:75–83.
  2. Centor RM et al. The diagnosis of strep throat in adults in the emergency room. Med Decis Making 1981;1:239–46.

Infectious Disease · Reviewed 2026-10-14 · Methodology