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Corrected Calcium for Albumin

Corrected calcium = measured calcium + 0.8 × (4.0 − albumin g/dL), or in SI units Ca + 0.02 × (40 − albumin g/L) mmol/L. Normal is about 8.5–10.5 mg/dL (2.10–2.60 mmol/L); measure ionised calcium when it matters.

  • Total serum calcium (mg/dL or mmol/L)
  • Serum albumin (g/dL or g/L)
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Interpretation

ResultMeaning
< 8.5 mg/dL (< 2.12 mmol/L)Hypocalcaemia
8.5–10.5 mg/dL (2.12–2.62 mmol/L)Normal
10.6–11.9 mg/dLMild hypercalcaemia
≥ 12 mg/dL (≥ 3.0 mmol/L)Moderate–severe hypercalcaemia

Formula

Corrected Ca (mg/dL) = Ca + 0.8 × (4.0 − albumin g/dL). SI: Corrected Ca (mmol/L) = Ca + 0.02 × (40 − albumin g/L).

Clinical pearls

  • Albumin correction is unreliable in critical illness, CKD and with abnormal pH; measure ionised calcium instead.
  • Some labs use a locally derived correction formula and reference albumin; follow your lab if it reports adjusted calcium.

Examples

FAQ

How do you correct calcium for low albumin?

Add 0.8 mg/dL to the measured calcium for every 1 g/dL that albumin is below 4.0 (or 0.02 mmol/L per g/L below 40 g/L).

When should I order ionised calcium instead?

In critically ill patients, advanced CKD, acid–base disturbances, or whenever the corrected value would change management.

Evidence

  1. Payne RB et al. Interpretation of serum calcium in patients with abnormal serum proteins. Br Med J 1973;4:643–6.

Nephrology & Electrolytes · Reviewed 2026-10-14 · Methodology