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Lille Model (Day 7, Alcoholic Hepatitis)

The Lille model assesses response to corticosteroids in severe alcohol-associated hepatitis using day-0 values and the change in bilirubin at day 7. A score ≥0.45 indicates non-response (6-month survival ~25%) and supports stopping steroids.

Age (years)
Albumin at day 0 (g/dL or g/L)
Bilirubin at day 0 (mg/dL or µmol/L)
Bilirubin at day 7 (mg/dL or µmol/L)
Creatinine at day 0 (>1.3 mg/dL = renal insufficiency) (mg/dL or µmol/L)
Prothrombin time at day 0

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Interpretation

Result	Meaning
< 0.45	Responder; 6-month survival ~85%
≥ 0.45	Non-responder; 6-month survival ~25%

Formula

R = 3.19 − 0.101 × age + 0.147 × albumin d0 (g/L) + 0.0165 × [bilirubin d0 − bilirubin d7] (µmol/L) − 0.206 × renal insufficiency (Cr >1.3 mg/dL) − 0.0065 × bilirubin d0 (µmol/L) − 0.0096 × PT (s). Lille = e^(−R) ÷ (1 + e^(−R)).

Clinical pearls

The model was built with prothrombin time in seconds; do not enter INR.
A day-4 Lille performs similarly in later validation, but this calculator implements the original day-7 model.

Examples

lille 50 yo alb 25 g/L bili day 0 300 umol/L day 7 200 umol/L cr 1.0 pt 20 Lille score: age 45, albumin 2.8, bilirubin 15 then 14 on day 7, creatinine 1.6, PT 25 s day 7 lille bili0 10 bili7 6 alb 3.0 age 40 creat 0.8 pt 16

FAQ

When should steroids be stopped in alcoholic hepatitis?

If the day-7 Lille score is ≥0.45 the patient is a non-responder and steroids are usually stopped.

What values does the Lille score need?

Age, day-0 albumin, bilirubin and prothrombin time, renal insufficiency (creatinine >1.3 mg/dL), and day-7 bilirubin.

Evidence

Louvet A et al. The Lille model: a new tool for therapeutic strategy in patients with severe alcoholic hepatitis treated with steroids. Hepatology 2007;45:1348–54.

Hepatology & GI · Reviewed 2026-10-14 · Methodology