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Ranson Criteria for Acute Pancreatitis

Ranson's criteria score acute pancreatitis with 5 admission and 6 (non-gallstone) or 5 (gallstone) 48-hour criteria. A score ≥3 indicates severe pancreatitis; historical mortality is ~1% for 0–2, ~15% for 3–4, ~40% for 5–6 and near 100% for ≥7.

  • Etiology: Non-gallstone (e.g. alcohol); Gallstone (biliary)
  • Age (years)
  • White blood cell count (×10⁹/L or ×10³/µL)
  • Glucose (admission) (mg/dL or mmol/L)
  • LDH (admission) (U/L)
  • AST (U/L)
  • Hematocrit fall over 48 h (percentage points) (%)
  • BUN rise over 48 h (mg/dL or mmol/L)
  • Lowest serum calcium within 48 h (mg/dL or mmol/L)
  • Arterial PaO₂ within 48 h (non-gallstone only) (mmHg or kPa)
  • Base deficit within 48 h (mmol/L or mEq/L)
  • Estimated fluid sequestration over 48 h (L)
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Interpretation

ResultMeaning
0–2Mild; mortality ~1%
3–4Severe; ~15%
5–6Severe; ~40%
≥ 7Severe; ~100% (historical)

Formula

Non-gallstone — admission: age >55, WBC >16, glucose >200 mg/dL (11.1 mmol/L), LDH >350 U/L, AST >250 U/L; 48 h: Hct fall >10 points, BUN rise >5 mg/dL (1.8 mmol/L), Ca <8 mg/dL (2.0 mmol/L), PaO₂ <60 mmHg, base deficit >4, fluid sequestration >6 L. Gallstone — admission: age >70, WBC >18, glucose >220 mg/dL (12.2 mmol/L), LDH >400, AST >250; 48 h: Hct fall >10, BUN rise >2 mg/dL (0.7 mmol/L), Ca <8, base deficit >5, fluid sequestration >4 L. One point each.

Clinical pearls

  • The full score needs 48 hours; for early triage BISAP or SIRS are faster.
  • Leave any 48-hour item blank if unknown; it is then not counted and the result says how many were entered.
  • Mortality figures come from 1970s cohorts and overstate modern mortality.

Examples

FAQ

What Ranson score is severe pancreatitis?

Three or more Ranson criteria indicate severe acute pancreatitis.

Why are there two sets of Ranson criteria?

Ranson derived different thresholds for gallstone pancreatitis, which has higher admission age, WBC, glucose and LDH cut-offs, and drops PaO₂.

Evidence

  1. Ranson JH et al. Prognostic signs and the role of operative management in acute pancreatitis. Surg Gynecol Obstet 1974;139:69–81.
  2. Ranson JH. Etiological and prognostic factors in human acute pancreatitis: a review. Am J Gastroenterol 1982;77:633–8.

Hepatology & GI · Reviewed 2026-10-14 · Methodology