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CHADS-65 Algorithm (Canadian Cardiovascular Society) for AF Anticoagulation

The CCS "CHADS-65" algorithm recommends oral anticoagulation for AF if age ≥65 or any CHADS₂ risk factor (heart failure, hypertension, diabetes, prior stroke/TIA) is present; otherwise antiplatelet therapy if there is coronary or peripheral arterial disease; otherwise no antithrombotic.

  • Age (years)
  • Congestive heart failure (yes/no, +1)
  • Hypertension (yes/no, +1)
  • Diabetes mellitus (yes/no, +1)
  • Prior stroke or TIA (yes/no, +1)
  • Coronary or peripheral arterial disease (yes/no, +1)
—

Interpretation

ResultMeaning
Age ≥ 65OAC
Age < 65 with CHF, HTN, DM or stroke/TIAOAC
None of the above, but CAD or PADAntiplatelet (ASA)
NoneNo antithrombotic

Formula

Step 1: age ≥ 65 → OAC · Step 2: any of CHF, hypertension, diabetes, prior stroke/TIA → OAC · Step 3: CAD or PAD → antiplatelet · otherwise no antithrombotic

Clinical pearls

  • Female sex alone does not trigger anticoagulation under the CCS algorithm.
  • Patients with CAD/PAD who meet OAC criteria generally get an OAC alone once beyond the acute/stent period; follow CCS antithrombotic guidance for combinations.
  • Not for AF with mechanical valves or moderate–severe mitral stenosis, which need warfarin regardless.

Examples

FAQ

What is the CHADS-65 rule?

In Canadian guidelines, anyone with AF aged 65 or older, or with any CHADS₂ risk factor (CHF, hypertension, diabetes, stroke/TIA), should receive oral anticoagulation.

How does CHADS-65 differ from CHA₂DS₂-VASc?

CHADS-65 is a simpler yes/no pathway; it ignores female sex and treats age ≥65 alone as an indication for anticoagulation.

Evidence

  1. Andrade JG et al. 2020 CCS/CHRS Comprehensive Guidelines for the Management of Atrial Fibrillation. Can J Cardiol 2020;36:1847–1948.
  2. Macle L et al. 2016 Focused Update of the CCS Guidelines for the Management of Atrial Fibrillation. Can J Cardiol 2016;32:1170–85.

Cardiology · Reviewed 2026-10-14 · Methodology