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Pulmonary Embolism Severity Index (PESI)

PESI predicts 30-day mortality in acute PE from 11 clinical variables. Class I (≤65) and II (66–85) are low risk (0–3.5% mortality) and may suit outpatient treatment; classes III–V (>85) carry 3.2–24.5% mortality.

  • Age (years)
  • Sex: Male; Female
  • Cancer (active or history) (yes/no, +30)
  • Chronic heart failure (yes/no, +10)
  • Chronic lung disease (yes/no, +10)
  • Heart rate (/min)
  • Systolic blood pressure (mmHg or kPa)
  • Respiratory rate (/min)
  • Temperature (°C or °F)
  • Altered mental status (disorientation, lethargy, stupor or coma) (yes/no, +60)
  • Arterial oxygen saturation (SaO₂) (%)
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Interpretation

ResultMeaning
≤ 65Class I (0–1.6%)
66–85Class II (1.7–3.5%)
86–105Class III (3.2–7.1%)
106–125Class IV (4.0–11.4%)
> 125Class V (10.0–24.5%)

Formula

Age (years) · male +10 · cancer +30 · chronic heart failure +10 · chronic lung disease +10 · HR ≥ 110 +20 · SBP < 100 +30 · RR ≥ 30 +20 · temperature < 36 °C +20 · altered mental status +60 · SaO₂ < 90% +20

Clinical pearls

  • Classes I–II identify candidates for outpatient management if there are no other reasons to admit (bleeding risk, hypoxemia, social).
  • PESI does not include RV dysfunction or troponin; ESC risk stratification adds these for intermediate-risk patients.

Examples

FAQ

Which PESI classes can be treated as outpatients?

Classes I and II (score ≤85) have low 30-day mortality and may be suitable for outpatient treatment if no other admission criteria apply.

What is the difference between PESI and sPESI?

sPESI keeps 6 binary items and classifies patients as low risk (0 points) or not; it is quicker and performs similarly.

Evidence

  1. Aujesky D et al. Derivation and validation of a prognostic model for pulmonary embolism. Am J Respir Crit Care Med 2005;172:1041–6.

Cardiology · Reviewed 2026-10-14 · Methodology