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Wells Score for Pulmonary Embolism

The Wells PE score (0–12.5) estimates pretest probability of pulmonary embolism. Two-tier: ≤4 "PE unlikely" (D-dimer first), >4 "PE likely" (CT pulmonary angiography). Three-tier: <2 low, 2–6 moderate, >6 high.

  • Clinical signs and symptoms of DVT (yes/no, +3)
  • PE is the most likely diagnosis (or equally likely) (yes/no, +3)
  • Heart rate > 100 (yes/no, +1.5)
  • Immobilization ≥ 3 days or surgery in the previous 4 weeks (yes/no, +1.5)
  • Previous DVT or PE (yes/no, +1.5)
  • Hemoptysis (yes/no, +1)
  • Malignancy (on treatment, treated in last 6 months, or palliative) (yes/no, +1)
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Interpretation

ResultMeaning
≤ 4PE unlikely: D-dimer
> 4PE likely: CTPA
< 2 / 2–6 / > 6Three-tier: low / moderate / high

Formula

Clinical DVT signs 3 · PE most likely diagnosis 3 · HR > 100: 1.5 · immobilization ≥ 3 d or surgery < 4 wk 1.5 · previous DVT/PE 1.5 · hemoptysis 1 · malignancy 1

Clinical pearls

  • In "PE unlikely" patients, apply PERC first if gestalt is low; age-adjusted D-dimer (age × 10 µg/L over 50) reduces imaging.
  • "PE most likely diagnosis" is subjective and drives most of the score; inter-rater agreement is modest.

Examples

FAQ

What Wells score means PE is likely?

A score above 4 classifies PE as likely, and CT pulmonary angiography is recommended; 4 or less is PE unlikely and a D-dimer is done first.

Can a negative D-dimer rule out PE?

Yes in patients classified as PE unlikely (Wells ≤4); not in those with PE likely, who need imaging.

Evidence

  1. Wells PS et al. Derivation of a simple clinical model to categorize patients probability of pulmonary embolism. Thromb Haemost 2000;83:416–20.
  2. Wells PS et al. Excluding pulmonary embolism at the bedside without diagnostic imaging. Ann Intern Med 2001;135:98–107.

Cardiology · Reviewed 2026-10-14 · Methodology